European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION, EVALUATION AND OPTIMIZATION OF ORODISPERSIBLE TABLET OF METFORMIN HYDROCHLORIDE

Rahil G. Bhura*, Nilesh Patel, Mehul B. Vyas, Dr. Samir K. Shah

ABSTRACT

Aim of present work was to provide quick onset of action due to rapid dissolution and disintegration of tablet and to prepare and evaluate orodispersible tablet of Metformin Hydrochloride by direct compression method. In current research, orodispersible tablet was prepared by using different super disintigrants like crosspovidone (CRP), sodium starch glycolate (SSG) and cross carmallose sodium (CCS). The formulations were prepared by using direct compression method. Nine batches were prepared as per 32 factorial design, to investigate the combined effect of independent effect of variables (X1= amount of cross carmallose sodium and X2= amount of crosspovidone) on dependent variables (disintegration time and % drug release release in 10 min). The prepared fast dissolving tablets were evaluated for various physicochemical parameters, such as weight variation, hardness, thickness, friability, disintegration time, wetting time, % drug content and % in vitro drug release to optimize the formula. In preliminary trials two super disintegrants cross carmellose sodium and cross povidone were found more effective as compared to sodium starch glycolate. 32factorial design results showed that amount of cross carmellose sodium and amount cross povidone had significant effect on disintegration time and % drug release. Out of all nine batches batch F5 (cross povidone 30 mg and cross carmellose sodium 30 mg) was selected as optimized batch with lower disintegration time (10.15 sec) and % drug release (93.28%). So from this work it was concluded that orodispersible tablets of metformin hydrochloride were prepared successfully.

Keywords: Orodispersible tablet, Metformin Hydrochloride, Direct compression, Supurdisintegrants.