Abstract
ANALYTICAL METHODOLOGIES FOR DETERMINATION OF ITRACONAZOLE AND TERBINAFINE HCL IN BULK AND PHARMACEUTICAL DOSAGE FORMS: AN OVERVIEW

S. B. Kshirsagar*, D. N. Holkar, S. G. Jadhav, R. N. Kale and G. K. Dyade

ABSTRACT

Itraconazole is one of the triazole antifungal agent used in treatment of fungal infection. Itraconazole inhibits cytochrome P-450-dependent enzyme resulting in impairment of ergosterol synthesis. Terbinafine Hydrochloride is synthetic allylamine antifungal agent inhibit synthesis of ergosterol by inhibiting fungal squalene monooxygenase (squalene 2,3-epoxidase), an enzyme that is a part of fungal cell wall synthesis pathway. The most commonly adopted methods for determination both drugs are UV-Visible Spectroscopy, HPLC (High Performance Liquid Chromatography), RP-UPLC (Reverse Phase-Ultra Performance Liquid Chromatography), HPTLC (High Performance Thin Layer Chromatography). This article provides critical review on the methodologies available for qualitative and quantitative determination of Itraconazole and Terbinafine HCL in bulk and pharmaceutical dosage forms.

Keywords: Antifungal, Itraconazole, Terbinafine Hydrochloride, RP-UPLC, HPTLC, RP-HPLC, UV-Spectroscopy.


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