Abstract
A REVIEW ON ANALYTICAL METHODS FOR ESTIMATION OF REPAGLINIDE IN BULK AND IN PHARMACEUTICAL DOSAGE FORMS

D. N. Holkar*, S. B. Kshirsagar, S. G. Jadhav, R. N. Kale and G. K. Dyade

ABSTRACT

Repaglinide is the meglitinide class drug used in the management of type 2 diabetes mellitus also known as non-insulin dependent diabetes mellitus (NIDDM) to reduce blood glucose level. For determination of Repaglinide in bulk and in pharmaceutical dosage forms, several analytical methods like UV, HPLC and HPTLC techniques are found in literature. Methods using human and rat plasma, stability in different solvents are also available for repaglinide. For qualitative and quantitative estimation of not only Repaglinide but also for its related degradants in bulk formulations and biological fluids these analytical methods can be used. The present study depicts the review on analytical methods for the estimation of repaglinide and its combination with another antidiabetic drugs.

Keywords: Antidiabetic, Repaglinide, RP-HPLC, HPTLC, UV-Spectroscopy.


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