European Journal of Biomedical and Pharmaceutical Sciences

GOLD NANOSHELL: SYNTHESIS, CHARACTERIZATION, EXAMPLE ANDAPPLICATION IN CANCER THERAPY

Dr. Sonali Mahaparale* and Vrushali B. Londhe

ABSTRACT

Cancer is the 2nd and 3rd leading cause of the death after heart disease and stroke in US and in developed countries resp. Although hyperthermia has been a method of a treatment of cancer for decades traditional way of heating tissues involve invasive catheters or whole body heating system. The use of nanoshells involves the NIR heating of nanoshells without harming healthy tissues. The GNSs are spherical, ranging from 10-200nm, which is composed of dielectric core covered by a thin gold shells & it possesses optical, physical & chemical properties. These GNSs shows cancer detection, cancer treatment, cellular imaging & medical biosensing in the previous method. [1] Here in the current method the customized the Lee-Meisel method, to prepare small & monodisperse AgNSs of diameter 17-25±4nm. [3] The example of fabricated nanoparticles which is mesoporous silica loaded doxorubicin covered with a thin layer of pegylated gold. The prepare GNSs were characterized by TEM, UV-VIS spectroscopy, FTIR, Raman spectroscopy, X-ray photodetection spectroscopy, & examine relative solubility in a variety of solvents. [1]

Keywords: Self assembled monolayers (SAMs), surface Plasmon resonance (SPR), alkanethiol functionalization, sacrifial silver nanoparticles (AgNPs).