BIOCHEMICAL PROFILING OF CORD BLOOD SAMPLES IN TERM HEALTHY NEONATES; A STUDY REPORT
Dojum Boje*, V. K. Kori, K. S. Patel and Gopinath Agnihotram
ABSTRACT
Introduction: Cord blood biochemical parameters reflect the health status of the newborn which may be subjected to alterations due to inflammatory, metabolic and immunological disorders during pregnancy. Cord blood can act as a screening aid to identify various metabolic disorders and also facilitate early detection, diagnosis and intervention of the conditions that can affect a child’s long term health or survival. Aim and Objective: The present study was carried out for the purpose of screening the term neonates and to establish the reference range of Biochemical parameters of umbilical cord blood. Methods: 75 Term Neonates with normal birth weight born out of uneventful pregnancy were taken as representative sample from Jamnagar city after the careful sampling of cord blood .The processing of the blood samples and biochemical analysis of parameters were carried out as per the laboratory standard operating procedure. Result: The observed range of Biochemical parameters (±SD) for Glucose, Serum Cholesterol was found to be 58.83 – 88.84 mg/dl and 36.65 – 84.17 mg/dl, Blood Urea. Serum Creatinine exhibited range of 10.18 – 20.33 mg/dl, and 0.61 – 0.89 mg/dl. Total Protein, Serum Albumin, Serum Globulin, were 4.96 – 6.06 gm/dl , 3.01 – 3.53gm/dl, 1.73 – 2.62 gm/dl respectively which shows close proximity to proposed biochemical ranges obtained in the other study except Sr. Cholesterol (68±27) and blood Urea (20±5) which were comparatively lower in the present study. Conclusion: Umbilical cord blood analysis for biochemical parameters should be routinely practised for evaluation of the status of the newborn and also the obtained biochemical reference range can be used as a guide for future analysis.
Keywords: Umbilical Cord Blood, Term Neonates, Biochemical reference range.
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