European Journal of Biomedical and Pharmaceutical Sciences

ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF ACALYPHA INDICA ANDWRIGHTIA TINCTORIALEAVES EXTRACTS: A COMPARATIVE STUDY

Divya Lakshmi S.*, Anitha A. D. and Nishanthini H.

ABSTRACT

In the present study, the bioactive compounds in the leaves of Wrightiatinctoria and Acalyphaindica were extracted with chloroform and ethanol as solvents. The crude extractswere tested against, bacterial strains such as Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa and fungal strains such as Candida albicans, Microsporumgypseumand Trichophyton which are being the causative agents of various skin infections in humans using agar disc diffusion method. The antibacterial and antifungal activity of extracts of two leaf samples were compared. This study showed that the ethanol extract of A.indica exhibited a maximum zone of inhibition of 27mm at 1000μg/ml against the Tricophyton than the W.tinctoria leaf extracts. The chloroform extract of W.tinctoria displayed a maximum zone of inhibition of 14mm, 10mm, 18mm, 14mm and 15mm at 1000μg/ml against Staphylococcusaureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicansand Microsporumgypseumrespectively than the Acalyphaindica leaf extracts.

Keywords: Acalyphaindica, Wrightiatinctoria, Antibacterial, Antifungal, Skin infection.