Abstract
EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF AQUEOUS EXTRACT OF AVERRHOA BILIMBI IN MICE

Jasmine Shalet Souza*, Karunakar Hegde, and A. R. Shabaraya

ABSTRACT

Objective: To evaluate the antidepressant activity of aqueous extract of Averrhoa bilimbi (AEAB) fruits in mice. Methods: The antidepressant activity of aqueous extract of Averrhoa bilimbi was evaluated using tail suspension test, forced swim test and hole board test. The test was carried out at two different doses of AEAB (0.5ml and 1ml). The treatment was given for 11 days and the antidepressant activity was tested on 0th and 11th day of the treatment. Imipramine (10 mg/kg) was served as standard in all the models. Results: AEAB treatment showed a significant antidepressant activity compared to control. The duration of immobility reduced significantly in case of TST and FST and a increase in number of head dips were observed in case of hole board test. Averrhoa bilimbi showed dose dependent antidepressant action with better action at higher dose. Conclusion: The present study suggested that the aqueous extract of Averrhoa bilimbi is effective against depression.

Keywords: Averrhoa bilimbi, FST, TST, Hole board Test.


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