European Journal of Biomedical and Pharmaceutical Sciences

A STUDY OF MAGNESIUM CONCENTRATION AS A NOVEL PREDICTOR IN PATIENTS WITH NON INSULIN DEPENDENT DIABETIC NEPHROPATHY

Dr. P.V. Satyanarayana, Dr. S. S. Bhagat*, Dr. R.K. Padalkar, S. M. Patil, R. A. Ghone

ABSTRACT

Diabetic Nephropathy is one of the well known complication of diabetes mellitus [DM]. It has been reported in several studies that the metabolism of trace elements like cupper magnesium has altered in diabetes. Aim of the present study was to investigate serum magnesium, creatinine, blood urea and other baseline parameters in diabetic nephropathy patients. The study includes total 65 diabetic nephropathy patients and 65 controls with the age group of 40-65 years. Fasting Blood Sugar, Post Prandial Blood Sugars were determined by using the Glucose Oxidase/ Peroxidase method, estimation of blood urea by Berthelot method, serum creatinine by modified Jaffe’s reaction commercial kit by using semiautoanalyser, serum magnesium by colorimetric xylidyl blue method using commercial kit by using semiautoanalyser. The Mean ± SD values of Fasting Blood Sugar, Post Prandial Blood Sugars, serum creatinine & blood urea (mg/dl) were increased significantly [p<0.001] and diminished serum magnesium (mg/dl) [p<0.001] in diabetic nephropathy when compared with the controls. Renal function is the major regulator of the serum magnesium level. Continues high levels of blood glucose and low magnesium leads to more distressing clinical complications in diabetic nephropathy. To check the serum magnesium and renal functions are one of the early detectors of diabetic nephropathy.

Keywords: hypomagnesaemia, Diabetic Nephropathy, Renal failure.