Abstract
FORMULATION AND EVALUATION OF DELAYED RELEASE TABLETS OF LANSOPRAZOLE

*B. Premkumar, K. P. Chandralekha, Makam Sirisha, K. Bindhumadhavi and A. Srinivasa Rao

ABSTRACT

The objective of the study was an attempt to formulate and evaluate delayed release tablets of lansoprazole which is a benzimidazole anti ulcer agent and is one of the most widely used drugs for treating mild and severe ulcers. The stability of lansoprazole a proton pump inhibitor is a function of pH and it rapidly degrades in acidic medium of the stomach, but has acceptable stability in alkaline conditions. The present study demonstrates that the lansoprazole tablets could be successfully intestine targeted by using pH dependent polymers in different concentrations. The drug and excipient compatibility study was performed by FT-IR and study revealed that there was no interaction between drug & excipient. The tablets were evaluated for various parameters like hardness, friability, weight variation, percentage drug content and in-vitro disintegration time, in-vitro dissolution study, drug release kinetic study and stability study. By observing the dissolution profile for all the formulations, F1 was the better formulation. From the result of this study it may be concluded that the colon targeted drug delivery tablets using a combination of two polymers in optimized concentrations can be used to increase the delayed action of drug release to deliver the drug in a delayed manner.

Keywords: Lansoprazole, polymers, direct compression technique, FTIR & in-vitro studies.


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