European Journal of Biomedical and Pharmaceutical Sciences

DETECTION OF IL-6 LEVEL AND THE DIAGNOSTIC VALUE OF ANTI-TOXOPLASMA GONDII IgM and IgG IN ABORTED WOMEN IN AL-NASIRIYA CITY/IRAQ

Alyaa A. Hafedh*

ABSTRACT

Toxoplasmosis is an important health care problem through the world caused by an intra – cellular parasite Toxoplasma gondii that infect a variety of hosts. In human, the parasite responsible for many illness such as abortion, stillbirth and congenital anomalies. Il-6 is an important cytokine in immune response and it play important role in antibody production and increase cytotoxicity of NK and cytotoxic T—cells. The aim of the current study is determination of the prevalence of anti-T.gondii IgM and IgG in aborted women and the role of IL-6 during infection. A total of ( 414 ) aborted women included in this study and ( 30 ) apparently healthy women as control group, the serum was tested By chemoluminescent and ELISA to detects anti- T.gondii antibody and for determination of IL-6 levels. The results shows that the anti-T.gondii IgM was not detected in the serum of women under study. While, anti-T.gondii IgG was detected in 89 (27.38 % ) of aborted women with high significant differences under ( P<0.001 ) and the mean of IL-6 level was high ( 19.83 pg/ml ) in aborted women in compared with control group ( 5.25 pg/ml ) with high significant differences ( P< 0.001 ). In brief, the prevalence of toxoplasmosis was high among aborted women by detection of specific IgG antibody which have a high diagnostic value in compared with specific IgM antibody, IL-6 play an important role during the course of infection by T. gondii in aborted women.

Keywords: Toxoplasmosis, cytokine, serological diagnosis.