European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION DEVELOPMENT & EVALUATION OF CANDESARTAN CILEXITIL MUCOADHESIVE BUCCAL FILMS

K. Prema Kumari*, T. Malyadri and P. Sreenivasaprasana

ABSTRACT

Candesartan cilexitil useful in the tretament of hypertension having Angiotensin II receptor antagonist activity Buccoadhesive films of candesartan were prepared by solvent-casting method using novel polymers to improve the efficacy and bioavailability than the conventional formulations. The Prepared buccal films were evaluated for their weight, thickness, surface pH, swelling index, drug content uniformity, in vitro residence time, folding endurance in vitro release and permeation studies. the formulation C11 contain polyox to prepare sustained release mucoadhesive films of Candesartan as this formulation retards the release rate upto 8hrs and at the end of 8 hrs the release rate was found to be highest (i.e., 99.6%). Formulation C11showed good swelling, a convenient residence time and promising extended drug release, which can be selected for the development of buccal film for effective therapeutic use. The data observed from this study highlight the feasibility of the buccal route as a viable option for delivery of candesartan cilexitil.

Keywords: Buccal film, Candesartan cilexitil, vivo studies.