Abstract
FORMULATION DEVELOPMENT & EVALUATION OF CANDESARTAN CILEXITIL MUCOADHESIVE BUCCAL FILMS

K. Prema Kumari*, T. Malyadri and P. Sreenivasaprasana

ABSTRACT

Candesartan cilexitil useful in the tretament of hypertension having Angiotensin II receptor antagonist activity Buccoadhesive films of candesartan were prepared by solvent-casting method using novel polymers to improve the efficacy and bioavailability than the conventional formulations. The Prepared buccal films were evaluated for their weight, thickness, surface pH, swelling index, drug content uniformity, in vitro residence time, folding endurance in vitro release and permeation studies. the formulation C11 contain polyox to prepare sustained release mucoadhesive films of Candesartan as this formulation retards the release rate upto 8hrs and at the end of 8 hrs the release rate was found to be highest (i.e., 99.6%). Formulation C11showed good swelling, a convenient residence time and promising extended drug release, which can be selected for the development of buccal film for effective therapeutic use. The data observed from this study highlight the feasibility of the buccal route as a viable option for delivery of candesartan cilexitil.

Keywords: Buccal film, Candesartan cilexitil, vivo studies.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW NOVEMBER ISSUE PUBLISHED

    NOVEMBER 2020 Issue has been successfully launched on 1 November 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT