Abstract
ROLE OF AN INDIGENOUS GRANULE FORMULATION ON RAJONIVRITTI-JANYA LAKSHANAS (HYPOESTROGENISM)

*Dr. Pednekar R. Madhuri, Dr. Makim Rita, Dr. Vasudevan Asokan and Dr. Kumbar Jyoti

ABSTRACT

Menopause is the permanent cessation of menses due to physiological changes of ageing due to depletion of oocytes. Rajonivritti is the term mentioned in Ayurved which denotes Swabhavika raja kshaya. It is estimated that as many as 85% of postmenopausal women have experienced a menopause related symptom in their lifetime. Conservative therapies include Hormonal replacement therapy and self-management techniques. Prevalence of HRT use among menopausal women is 45years and above. As HRT has got its own limitations, so effort is been done to replenish the oestrogen through Phytoestrogen to post-menopausal women. To enhance palatability and ease the mode of administration the drugs were modified as khanda kalpana i.e. granules. Literary review of menopausal changes and phytoestrogenic activity of indigenous granule formulation. To formulate simple, economical, palatable health drink for postmenopausal women and to evaluate its efficacy in improving the QoL. A single blind clinical study on 40 menopausal women with pre-test and post-test design with an indigenous granule formulation administered 10gms twice daily with milk for the period of 3 months. This khanda kalpana showed marked improvement in 82.5% of women, with improvement in both subjective and objective parameters. This study shows that the drug is effective in post-menopausal women, the statistical data was significant with P < 0.0001. No adverse effect of the drug was observed during the study. Thus the health drink formulated with the indigenous drugs was beneficial in improving menopausal symptoms along with increasing the serum oestradiol and calcium levels.

Keywords: Hormone replacement therapy, Khanda kalpana, Phytoestrogens, Rajonivritti, Raja kshaya.


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