Abstract
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF MANNICH BASES OF COUMARINS

M. Sumakanth*, M. Sukanya and K. Sruthi

ABSTRACT

A series of Mannich bases of coumarin derivatives have been synthesized and were evaluated for their antibacterial activity. The starting material 7-Hydroxy-4-Methyl Coumarin which was prepared by Pechmann condensation was subjected to O-ethylation at 7-Position to yield 7-Ethoxy-4-Methyl Coumarin. The title compounds were inturn prepared by the mannich condensation of 7-Hydroxy/7-Ethoxy-4-Methyl Coumarin with a series of secondary amines. The structure of newly synthesized coumarin derivatives have been established on the basis of spectral (IR, 1H NMR, Mass) data. The synthesized compounds were screened for anti bacterial activity against various gram positive and gram negative strains. The compounds demonstrated moderate to significant anti bacterial activity.

Keywords: Mannich bases, Pechmann condensation, Coumarin, Anti bacterial activity.


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