European Journal of Biomedical and Pharmaceutical Sciences

COMPARISON OF ANTI-EMETIC EFFICACY OF PALONOSETRON VS ONDANSETRON FOR THE PREVENTION OF PONV

Tandon Sahil and Agrawal Nipun*

ABSTRACT

Background: Post operative nausea and vomiting (PONV) is a common problem following general anaesthesia The aetiology for PONV is multifactorial. Ondansetron is the first 5HT3 antagonist available commercially. Palonosetron is the most recently introduced member of this class. Aim: To evaluate the efficacy of palonosetron compared with ondansetron for preventing PONV in patients undergoing laparoscopic cholecystectomy surgeries. Material and Methods: In this randomized comparative study a total of 100 patients were enrolled and divided equally into two groups, group A (Ondensetron 8 mg) and group B (Palanosetron 0.075 mg). The occurrence of nausea and vomiting was noted. The comparison of normally distributed continuous variables between the groups was performed using Student’s t test. P<0.05 was considered statistically significant. RESULTS: There were no statistically significant differences between the two groups in terms of demographic characteristics There was no significant difference in episodes of vomiting between the two groups at 0 to 2 hrs, 2 to 6 hrs and 6 to 24 hrs. CONCLUSION: Both ondansetron and palonosetron are equally effective in the immediate post operative period but palonosetron is more effective over 24 hour period.

Keywords: Ondansetron, Palonosetron, PONV, 5-HT3 Receptor Antagonists.