European Journal of Biomedical and Pharmaceutical Sciences

MICROALBUMINURIA AS A MARKER OF SEVERITY AND PROGNOSIS IN ACUTE ISCHEMIC STROKE IN NON-DIABETIC PATIENTS

Dr. Abhishek B.Vadher*, Dr.Manin Chaudhary, Dr.Yash Shah, Dr.Vaibhav Patel, Dr.Karthik Reddy, Dr.Harsh Chapadia

ABSTRACT

Background: Objective of this study was to find co-relation between microalbuminuria and stroke severity based on NIH stroke scale and Modified Rankin Scale. Methods: The present study comprises 46 patients, with history and clinical features suggestive of acute ischemic stroke, and age and sex matched 46 controls, admitted in Shree Sayaji General Hospital, Baroda during January 1, 2014 to November 30, 2014.The severity of stroke was assessed using The National Institute of Health Stroke Scale (NIHSS) on admission. The Modified Rankin Scale was used to assess the outcome. Data collected was analyzed using Odd’s ratio and Chi-square test. Results: The patients with recent ischemic stroke were 5.31 times more likely to have microalbuminuria when compared to the controls (p value = 0.0001649). Presence of microalbuminuria was associated with loss of consciousness (p value= 0.025). Patients with microalbuminuria had higher NIHSS score on admission; p-value <0.05 (highly significant), and thus correlating with increased severity and poor prognosis. Patients with microalbuminuria had higher MRS score; p-value <0.05 (highly significant), and thus correlating with poor prognosis. Conclusions: Our results indicate that presence of microalbuminuria is associated with an increased severity and poorer short term prognosis. Thus, they may act as indicators of severity and short term prognosis in patients with acute ischemic cerebrovascular stroke.

Keywords: Microalbuminuria, Ischemic stroke, cerebrovascular event.