Abstract
PREGNENOLONE SULPHATE REVERSED KETAMINE INDUCED BEHAVIORAL CHANGES IN RATS

Mohd. Rashid Iqbal*, Sudhir Mishra and Yam Nath Paudel

ABSTRACT

Pregnenolone and its derivatives have been implicated in neuroprotection and enhance NMDA receptor neurotransmission pointing out their therapeutic potential in schizophrenia. This study was aimed to evaluate the effects of pregnelonone sulphate (Preg S) on behavioural changes and markers of oxidative stress induced by ketamine (Ket) in rats. All rats received intraperitoneal (i.p) injection daily for 14 days with different drug treatments viz. Preg S (11.86 mg/kg), risperidone (2 mg/kg/day) alone and in combination with ketamine (30 mg/kg). Different behavioural tests which included elevated plus maze, spontaneous alternation behaviour, locomotor activity tests were performed after 24 hrs of last dosing followed by the estimation of markers of oxidative stress and acetylcholine esterase (AchE) activity in rat’s brain. Ket produced significant changes in behaviour resembling to that of negative symptoms and memory impairment seen in schizophrenic patients. Preg S treated rats spent more time in open arm in elevated plus maze test, decreased percentage alternation and improved locomotor activity as compared to Ket treated rats. The levels of antioxidants such as superoxide dismutase (SOD) and reduced glutathione (GSH) were reduced while thiobarbituric acid reactive substances (TBARS) were elevated. Preg S administration normalized the antioxidant parameters. Preg S improved learning and memory in elevated plus maze, spontaneous alternation behaviour, locomotor activity, decreased AChE activity and reduced oxidative stress. Thus, we may conclude that Preg S offered neuroprotective and antioxidant effect in Ket induced behavioural symptoms.

Keywords: Pregnenolone sulphate, ketamine, neuroprotective, antioxidant, schizophrenia.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW OCTOBER ISSUE PUBLISHED

    OCTOBER 2020 Issue has been successfully launched on 1 October 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT