CLINICAL OUTCOME IN DIRECT VERSUS SUPPRESSED HRT FOR FROZEN EMBRYO TRANSFER CYCLES
Dr. Roshini Gundapaneni*, Dr. N. Sanjeeva Reddy, Dr. Radha Vembu, Dr. Monna Pandurangi, Dr. N. Siddharth
ABSTRACT
Aim: To evaluate the effect of Direct versus suppressed Hormone Replacement therapy (HRT) on clinical outcome in Frozen embryo transfer cycles (FET). Material and methods: Study design: Retrospective observational study. A Total of 101 patients included in the study from August 2016 to Dec 2017.All patients were divided into two groups, Direct HRT group A (n-45) and Suppressed HRT group B (n-56). Outcome: Treatment duration and clinical outcome like implantation rate, chemical and Clinical pregnancy rates, Miscarriage rate. Results: All Suppressed HRT patients required significantly longer days of preparation (18.98±4.56 versus 16.93±2.12; p<0.05) in comparison to Direct HRT group. Higher ongoing pregnancy rate in suppressed HRT compared to direct HRT(42.8% versus 31.1%;p=0.48) However, There were no statistical differences in clinical outcomes and cycle characteristics between the two groups. Conclusions: Direct HRT, a method of Artificial FET is equally beneficial in FET cycle along with suppressed HRT as it has shorter duration of preparation and is more patient friendly.
Keywords: Hormone Replacement therapy, Frozen embryo transfer.
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