European Journal of Biomedical and Pharmaceutical Sciences

ANTI-HYPERCHOLESTEROLEMIC EFFECT OF ETHANOL FRUIT EXTRACT OF VANILLA (Vanilla planifolia Andrews) ON MALE MICE

Endang Nurcahyani, Rina Maryani*, Mohammad Kanedi, Endang L. Widiastuti

ABSTRACT

Hypercholesterolemia is a condition characterized by high levels of cholesterol in the blood. Vanilla is one among plants that has cholesterol-lowering substances, but research on this subject is still lacking. This study aimed to determine whether ethanol fruit extract vanilla (Vanilla planifolia Andrews) can be used as anti-hypercholesterolemia in mice induced by quail egg suspension. Male mice (n=20) were divided into five groups. Group-1 (negative control) was given only high-fat quail egg yolks suspension. Group-2 (positive control) was treated with simvastatin at the dose of 10 mg/kg. Whereas group-3, 4 dan 5 were given vanilla extract of 50, 100, dan 200 mg/kg body weight respectively. The results showed that ethanol fruit extract of vanilla at the dose of 200 mg/kg significantly reduced level of blood cholesterol compared with that of negative control. It is worth concluding that vanilla fruit extract potential to be used as anti-hypercholesterolemia.

Keywords: Anti-hypercholesterolemia, Cholesterol, Hypercholestrolemia, Vanilin, Vanilla planifolia.