European Journal of Biomedical and Pharmaceutical Sciences

TRANSDERMAL DRUG DELIVERY SYSTEM: A REVIEW ON ITS TYPES, BASIC COMPONENTS, PREPARATION METHODS AND RECENT ADVANCES

Lalita Chauhan*, Prerna Thakur and Sheetal Sharma

ABSTRACT

This review focuses on the recent advances in Transdermal drug delivery system which can be a used for the research and development of pharmaceutical dosage form for transdermal drug delivery. TDDS (transdermal drug delivery system) is the novel drug delivery system that offers a variety of significant clinical benefits over other dosage forms such as tablets, capsules and injections. TDDS overcome the problems that are encountered with oral route. Transdermal route is non-invasive that includes lack of first pass metabolism effect, high bioavailability and steady drug plasma concentration. A Transdermal Patch is the discrete dosage form that is placed on the skin to deliver specific dose of the medicine (drug) into the bloodstream over a period of time. Transdermal patch is a medicated adhesive pad, after application to the skin it releases the active ingredient at a constant rate over a period of several hours to days. Skin is the major site of application for both local and systemic effects. However, stratum corneum is the main barrier for the penetration of drug through the skin. Here in this article, we mainly highlights on main ingredients, preparation methods, advantages, disadvantages, types of TDDS, evaluation parameters, modern techniques of TDDS.

Keywords: TDDS, skin, evaluation, polymers.