European Journal of Biomedical and Pharmaceutical Sciences

CLINICOPATHOLOGICAL PROFILE OF WILMS’ TUMOR: STUDY FROM A TERTIARY CARE HOSPITAL

Dr. Pradeep Kumar Behera, Dr. Subhashree Subhasmita Dash, Dr. Asaranti Kar* and
Dr. Soudamini Mohapatra

ABSTRACT

Introduction: Nephroblastoma or Wilms’ tumour is the most common primary renal malignancy of childhood. Most often they are found in children 2 to 4 years old (median age for males and females respectively are 37 and 43 months).[1] The most important prognostic indicators for Wilms’ tumour are the histologic subtype and the stage at presentation. Despite being a malignant tumour, a survival rate of over 90% seen today due to the use of multimodal therapy.[2,3] The purpose of this study is to look at the morphological patterns of Wilms’ tumour Material and Methods: This is a prospective study of the cases of Wilms’ tumour in our institution over a 2- year period (from july 2016 to july 2018). The nephrectomy samples were received and grossing was given protocol. It was processed and stained with routine H and E stain. All cases were subjected to WT1 and Ki67 immunohistochemistry. Result: In this study, 28 patients had Wilms tumour with males 16(57.1%) and females accounting 12(42.9%). 15(53.6%) of the tumours were located on the right side while 13(46.4%) were seen on left side. Most of the tumours weighed between 501-1000 grams representing 11(39.2%). Necrosis was observed in 92.8% cases. 89.2% cases in histology exhibited triphasic morphology. Conclusion: The predominant histological pattern of Wilms’ tumour in our study is the triphasic pattern. It is most common in children between the age 2 to 4 years with average tumour weight of between 501 to 1000 grams.

Keywords: Wilms’ tumour, Favourable histology, WT1 IHC.