European Journal of Biomedical and Pharmaceutical Sciences

PHYTOCHEMICAL COMPOSITION AND HEPATOPROTECTIVE ACTIVITIES OF THE TOTAL AQUEOUS EXTRACT OF Phyllanthus muellerianus LEAVES IN DIABETIC RATS

Bahi Calixte*, Gnaléi Rabé Marcellin, Kambou Sansan Philippe, Tiekpa Wawa Justine and Coulibaly Adama

ABSTRACT

The African populations in general and ivorian in particular use the plants for their health problems. The objective of this work is to study the phytochemical composition and the hepatoprotective activities of the total aqueous extract of Phyllanthus muellerianus in diabetic rats. The different chemical groups have been demonstrated in the aqueous total extract by their characteristic reactions. Hepatoprotective activities total aqueous extract of Phyllanthus muellerianus was evaluated in Wistar rats during experimental streptozotocin induced diabetes mellitus. Glyceamia and transaminases (ASAT and ALAT) were evaluated after treatment of rats with total aqueous extract Phyllanthus muellerianus and Glucidoral®, a reference antidiabetic agent. The results show that the total aqueous extract of Phyllanthus muellerianus is very rich in polyphenols, rich in alkaloids and terpenes and moderately rich in flavonoids and quinones, does not contain tannins and saponosides, whereas blood glucose, transaminases and total bilirubin have decreased significantly. Then normalized in diabetic rats treated with total aqueous extract Phyllanthus muellerianus. The same results were obtained with Glucidoral®. Conclusion: The total aqueous extract Phyllanthus muellerianus contains the major chemical groups, decreases and normalizes blood glucose, serum transaminase levels, and total bilirubin in diabetic rats. It could play a hepatoprotective role and justify its use in traditional medicine in the treatment of liver diseases.

Keywords: Phyllanthus muellerianus, hepatoprotective, transaminases, total bilirubin.