European Journal of Biomedical and Pharmaceutical Sciences

CONCURRENT MULTIPLE STIS IN HIV INFECTED PATIENTS

*Sudha Vani Damarla, Sagar Kotagiri, Padma Akurati and Dr. Gurram Nasimharao Netha

ABSTRACT

Background: HIV and other sexually transmitted infections (STIs) synergize to aggravate the associated morbidity of each other in the human body. Various studies have established the epidemiologic synergy between STIs and HIV. Presence of STIs increases the risk of either the acquisition or transmission of HIV by 3-5 times (especially in ulcerative diseases & diseases associated with discharges).[1] However there are few studies on individuals with more than one concurrent STI. The aim of our study is to determine the number of HIV positive patients with more than one concurrent STI. Materials and Methods: The present study comprised of 100 consecutive cases of HIV positive patients with STIs attending the outpatient department of DVL, Gandhi Hospital, Secunderabad, from January 2015 to June 2016. Detailed history, demographical data, and clinical features were recorded. All the patients were screened for common STIs. Results: Of the 100 patients included in the study, 72% (72) were males and 28% (28) were females. Maximum number of patients were in the age group 27-36 years (43%). Out of 100 patients 18(18%) had concurrent multiple STIs. Of these 18 patients with concurrent multiple STIs, 22.2% had genital herpes and genital candidiasis. Other multiple STIs were genital herpes and genital warts (11.1%), genital candidiasis and molluscumcontagiosum (11.1%),genital herpes and syphilis (11.1%), genital warts and syphilis (11.1%), genital candidiasis and syphilis (11.1%), hepatitis-B with genital warts (5.5%), hepatitis-B with genital candidiasis (5.5%), hepatitis-B with genital herpes (5.5%) and genital herpes with gonorrhoea (5.5%). Conclusion The pattern of multiple STI HIV co-infection and the clinical severity of such co-infection may serve as an indicator of the type of host–pathogen interaction determining the outcome of infection. Such multiple STI associations may not simply reflect an epidemiological association based on prevalent strain/agents in a particular setting. It may be an indicator to an evolutionary principle of parasite interactions using the susceptible host as a milieu.

Keywords: Concurrent STIs, co-infection, HIV.