European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF THERMOREVERSIBLE IN SITU NASAL GEL OF ZOLMITRIPTAN

Shubhangi C. Daswadkar* and Jyoti D. Gaikwad

ABSTRACT

The aim of present research work was to prolong the residence time at site of absorption by formulating Zolmitriptan thermo reversible mucoadhesive in-situ intranasal gel (TMISG) by using cold technique which forms a gel at the nasal mucosal temperature and contains a natural mucoadhesive polymer obtained from Trigonellafoenum-graecum L. (FSM) and characterized by gelation time, gelation temperature, pH, rheological studies, mucoadhesive strength, ex-vivo drug release, in-vivo pharmacokinetic study in rats. The study procedure involved extraction of mucoadhesive agent (FSM) which increases the residence time, will enhance the bioavailability of the ZMT. The mucoadhesive strength and viscosity of FSM polymer was found to be higher in comparison to the synthetic polymers, ie HPMC and carbopol 934 which are conventionally used for a similar purpose. The thermoreversible in-situ gelation was achieved by the use of poloxamer 407. The optimized nasal in situ gel shows gelation temperature 32˚C, and drug release 70.4% after 8 hrs.

Keywords: ZMT, TMISG, CNS, Fenugreek seed mucilage, in situ gel.