Abstract
FORMULATION AND EVALUATION OF THERMOREVERSIBLE IN SITU NASAL GEL OF ZOLMITRIPTAN

Shubhangi C. Daswadkar* and Jyoti D. Gaikwad

ABSTRACT

The aim of present research work was to prolong the residence time at site of absorption by formulating Zolmitriptan thermo reversible mucoadhesive in-situ intranasal gel (TMISG) by using cold technique which forms a gel at the nasal mucosal temperature and contains a natural mucoadhesive polymer obtained from Trigonellafoenum-graecum L. (FSM) and characterized by gelation time, gelation temperature, pH, rheological studies, mucoadhesive strength, ex-vivo drug release, in-vivo pharmacokinetic study in rats. The study procedure involved extraction of mucoadhesive agent (FSM) which increases the residence time, will enhance the bioavailability of the ZMT. The mucoadhesive strength and viscosity of FSM polymer was found to be higher in comparison to the synthetic polymers, ie HPMC and carbopol 934 which are conventionally used for a similar purpose. The thermoreversible in-situ gelation was achieved by the use of poloxamer 407. The optimized nasal in situ gel shows gelation temperature 32˚C, and drug release 70.4% after 8 hrs.

Keywords: ZMT, TMISG, CNS, Fenugreek seed mucilage, in situ gel.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2024 Issue has been successfully launched on 1 MAY 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT