Abstract
FORMULATION DEVELOPMENT AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEMS FOR PRAVASTATIN PRESSCOATED TABLETS

K. Sai*, K. Ashok, D. Dhachinamoorthi

ABSTRACT

Pravastatin is a cholesterol-lowering agent that belongs to a class of medications known as statins. It was derived from microbial transformation of mevastatin, the first statin discovered. It is a ring-opened dihydroxyacid with a 6’-hydroxyl group that does not require in vivo activation. The Aim and objective of this work is to the development and evaluation of press coated tablets using core tablets with superdisntegrants like crospovidone & CCS and polymers like Ethyl cellulose, HPMC K15M. From the reproducible results obtained from the executed trails of core and press coated tablets it can be concluded that P6 of core tablet and P3F5 of coated tablet were maintained lag phase upto 6hrs and brust release was at 7th hr and followed by maximum release at the end of 8th hr, so it is selected as optimized formulations for designing Pulsatile device. Therefore the study proved that coated Pravastatin can be successfully used as a time dependent modified Chronopharmaceutical formulation. Finally from the above results we can conclude that pulsatile drug delivery system of Pravastatin can be formulated using Ethyl cellulose and HPMC K15M.

Keywords: Pravastatin, CCS, Crospovidone, Ethyl cellulose, HPMC K15M.


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