THE POTENT ROLE OF SMART CHITOSAN NANOPARTICLES ON ATTENUATION OF TESTICULAR DAMAGE CIMETIDIN –INDUCED IN SWISS ALBINO MICE
Fatma M. Zalok, Samia M. Madbouly, Entsar S. Abdouh and Doaa M. Elnagar*
ABSTRACT
The present study was carried out to investigate the ameliorative effective of chitosan NPS on testicular damage induced by cimetidine. Mice were randomly divided into 4 groups, the first group served as control group, the second group received oral administration of chitosan NPS 12ml/kg, the third group received oral administration of 400mg/kg cimetidine, and the fourth group received oral co-administration of chitosan NPS and cimetidine. Results showed highly significant increase of prolactin and decrease of testosterone in the group received cimetidine in addition to serve pathological alterations in the testicular tissue represented by increasing tubular area due to elongation of seminiferous tubules disorganization of spermatogonia and absence of the most stags of spermatocytes, with low pathological score, in addition to intense incidence of caspase-3 referred to apoptosis. Where as, co-administration of chitosan NPS with cimetidine resulted in significant decrease of prolactin and increase of testosterone besides to improved testicular tissue with raising pathological score and less appearance of apoptosis.
Keywords: Cimetidine – chitosan NPS – testicular pathology- Caspase-3.
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