Abstract
DEVELOPMENT OF POTENT AND STABLE LYOPHILIZED SABIN FORMULATED LIVE ATTENUATED BIVALENT ORAL POLIO VACCINE

Amit Kumar* and Vaibhav Tomar

ABSTRACT

Current study was performed with aim to develop new lyophilized Sabin formulated bivalent Oral Polio Vaccine for oral administration purpose by using as such liquid form of available Sabin formulated bivalent Oral Polio Vaccine and also investigated various quality attributed in our laboratory such as potency, stability, identity, sterility, pH, and kanamycin antibiotic activity at room temperature for three months. The result of the investigations revealed that the newly developed vaccine is equally potent in comparison to currently using liquid Sabin formulated bivalent Oral Polio Vaccine and also found stable at room temperature for three months. The study may help to eliminate the cold chain system during transportation, storage and vaccination and also useful for its shelf life.

Keywords: Liquid sbOPV, Lyophilization, Lyophilized sbOPV, Quality attributes, Potency, Stability.


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