OXIDATIVE CLEARANCE IN AGE REALATED MACULAR DEGENERATION: EFFECTS OF NATURAL ANTIOXIDANTS SUPPLIMENTATION
Prof. Souvik Banerjee, Prof. Krishnajyoti Goswami*, Prof. Asok Bandyopadhyay and Prof. Chittaranjan Maity
ABSTRACT
Malonaldehyde and dehydroascorbic acid were found to be highly increased in Age Related Macular Degeneration, a retinal disorder, suggesting intense oxidative stress in this condition. Superoxide dismutase was also found to be increased probably as a part of natural defensive mechanism against oxygen damage. Reduced level of gluthione peroxidise in this condition seems to be associated with lipid peroxidation. The abnormal glucose utilisation and insulin response to glucose load found in the study cases has been attributed to pancreatic dysfunction and/or receptor-mediated mechanism which could be the toxic manifestation of dehydroascorbic acid. High triglyceride, very low density lipoprotein cholesterol and a high triglyceride to high density lipoprotein cholesterol ratio suggest the relevant risk of clinical vascular disorders. Ascorbic acid, Vitamin E and mixed carotenoids supplementation separately to these patients could reverse the altered biochemical parameters more or less in the similar fashion. The mode of action of these antioxidants probably cantered around the free radical metabolism.
Keywords: Age Related Macular Degeneration, Oxidative Stress, Antioxidants, Plasma Lipids, Dehydroascorbic Acid.
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