European Journal of Biomedical and Pharmaceutical Sciences

AN ENIGMATIC CASE OF PLEURAL EFFUSION

Prof. G. N. Srivastava, Dr. Saurabh Mishra*, Dr. Ritamvara Oli, Dr. Thiru Anbarasan, Dr. Devanshu Mohaniya, Dr. Jaideep Singh Rajawat, Dr. Anish Saha, Dr. Mohit Mangla

ABSTRACT

Solitary fibrous tumor of pleura is extremely rare condition, a total of only 2000 cases are reported in literature till date. About 2/3rd of these tumours arise from visceral pleura and 1/3rd arise from parietal pleura. Grossly, they appear as firm, encapsulated yellow tumours, which may be vascular with prominent veins over their external surface. Histologically, characterized by uniform, elongated spindle cells and varied amount of collagen and reticular fibres. Cell markers- vimentin, CD34, CD99 and bcl-2 but negative for cytoplasmic keratins. 50% of cases are asymptomatic and rests present with dyspnoea, cough and chest pain. 25% of the cases are febrile without any evidence of infection. 10-20% cases present with pleural effusion. 20% of the cases have hypertrophic pulmonary osteoarthropathy (Pierre-Marie-Bamberg syndrome) which resolves within 4-5 months after surgical removal of the tumor. Paraneoplastic syndrome associated with SFTP is hypoglycaemia (Doege-Potter syndrome) which resolves within 3-4 days after surgical removal of the tumor. Treatment of choice is complete surgical removal.

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