European Journal of Biomedical and Pharmaceutical Sciences

TO STUDY ROLE OF MISOPROSTOL BY VARIOUS ROUTES IN MANAGEMENT OF THIRD STAGE OF LABOUR

Dr Rajendra Prasad Bugalia and Dr. Anuradha Salvi*

ABSTRACT

The most common cause of maternal mortality is postpartum haemorrhage, accounting for one third of maternal deaths. Recently misoprostol, a PGE1 analogue, has been reported to be effective in prevention of PPH. Aim: Was to study and analyse the role of misoprostol by various routes in management of third stage of labour. Material & methods: This hospital based randomized comparative study was conducted on 200 patients admitted for delivery. Misoprostol was given by oral, rectal and vaginal routes and compared with methyl ergotmetrine. In all the patients time and nature of placental delivery, amount of blood loss, need of other uterotonic agent, change in Hb after 48 hrs of delivery and any side effect of the drugs were noted. Results and Discussion- Mean duration of third stage of labour was minimum in ME (4.0 ± 3.2) group and maximum in vaginal misoprostol group (7.8 ± 3.6). Mean blood loss during third stage of labour was minimum in misoprostol rectal group (120 ± 10).Rectal route is best in terms of ease to administer, extremely rapid absorption effectiveness stability and safety profile regarding prevention of PPH.

Keywords: PPH, Misoprostol, Third stage of labour.