European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ON GENETIC PRINCIPLES OF DRUG RESISTANCE

*Nagma Begum, Dr. K. Sruthi, Sreelatha, Dr. M. Sumakanth

ABSTRACT

Drug resistance is the reduction in efficacy of a medication to cure a disease or condition. Today, antibiotic-resistance is rising due to dangerously high levels worldwide and threatening our ability to treat even common infectious diseases. consequently, understanding the diverse molecular mechanisms underlying resistance to antibiotics and other therapeutic drugs will aid in the development of new drugs to combat rising drug resistance. Bioinformatics provide the avenue in time and cost-effectiveness to screen potential compounds, alongside rational experimentation. Next-generation, sequencing and specific databases provide a valuable resource for the detection and identification of mutations of drug resistance. These include drug resistance mechanism, methods of transfer of resistance, examples of antibiotics, anticancer and strategies to combat drug resistance.

Keywords: Drug discovery, Drug resistance, Molecular mechanism, Multiple drug resistance, Next-generation sequencing, Persistence, Tolerance.