European Journal of Biomedical and Pharmaceutical Sciences

BUCCAL BIOADHESIVE DRUG DELIVERY –A PROMISING OPTION FOR CONVENTIONAL THERAPY

V. M. Vaidya*, Dr. N. S. Bhajipale, S. P. Deshmukh and A. G. Sinhe

ABSTRACT

Since, the last four decades, the concept of mucoadhesion has achieved a much valuable interest in the various fields of pharmaceutics. There are many advantages of mucoadhesive buccal drug delivery system that made this a novel drug delivery system for the local as well as systemic delivery of various drugs. The main advantage of this drug delivery system is that it prolongs the residence time of the dosage form at the site of application. Due to the high blood supply and relatively high permeability of the buccal mucosa, the buccal cavity is the best option for both local as well as systemic delivery of various drugs. This review concludes that the mucoadhesive drug delivery system was found to be a better alternative to the conventional oral route. It is a unique alternative to conventional drugs by virtue of its ability in overcoming hepatic metabolism, reduction in dose, frequencies and enhancing bioavailability. This delivery system will shows a controlled release of drug; ease of application and the formulation and evaluation of such systems does not have any complication. So we can expect that the mucoadhesive system may be one of the important dosage form in the future pharmaceutical and health care sector.

Keywords: Mucoadhesion; Permeation enhancers; Bioadhesive polymer.