Abstract
TO MASK THE BITTER TASTE OF RIZATRIPTAN BENZOATE AND DEVELOP WATER DISPERSIBLE TABLETS BY USING INDION 234 AND KYRON T-114

Vikrant V. Chilate*, Harsha V. Sonaye and Dr. C. A. Doifode

ABSTRACT

Rizatriptan benzoate is anti migraine drug. Report indicates that, it has very bitter taste, which deters its use in geriatrics patient thus not comply with prescription that results in high incidence of non-compliance and ineffective therapy. To mask the bitter taste of Rizatriptan benzoate and develop water dispersible tablets by using the combination of Indion 234 and Kyron T-114a well palatable and patient compliant Rapid disintegrating tablet could be successfully prepared using direct compression method. The prepared optimized tablet showed rapid disintegration as well as rapid dissolution. Thus the rapid disintegrating tablet of bitter drug having better taste and pleasant mouth feel can be successfully formulated.

Keywords: Rizatriptan benzoate, Indion 234, Kyron T-114 and water dispersible tablets.


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