European Journal of Biomedical and Pharmaceutical Sciences

CASE REPORT ON CARBAMAZEPINE INDUCED STEVENS JOHNSON SYNDROME IN TRIGEMINAL NEURALGIA

Dr. Darabadi Rispa*, Karanam Parinithi, Jandhyala Vyshnavi, Harika Rani Tadikamalla

ABSTRACT

Trigeminal neuralgia (TN or TGN) is a chronic pain disorder that affects the trigeminal nerve. The pain associated with trigeminal neuralgia represents an irritation of the nerve. The cause of the pain usually is due to contact between a healthy artery or vein and the trigeminal nerve at the base of the brain. This places pressure on the nerve as it enters the brain and causes the nerve to misfire. This intense, stabbing, electric shock-like pain is caused by irritation of the trigeminal nerve. The pain is intensely sharp, throbbing and shock-like and usually triggered by touching an area of the skin or by specific activities.[1] Anticonvulsant drug and Muscle relaxant are the common class of drugs used in the treatment of Trigeminal neuralgia.[1,2,9] A 65 years aged female patient attended OP with chief complaints of fever since 2 days and heavy rashes all over the body, skin blisters in the morning. She was on medication for Trigeminal neuralgia (carbamazepine 400 mg) since two days. Symptoms of STEVENS-JOHNSON SYNDROME were observed and it was found to be due to use of carbamazepine. With the advice of the physician the suspected drug was withdrawn and was replaced by Baclofen. Patient safety is essential in reporting the ADR’s and analyzing the medication error. Adverse drug reactions are an important concept which leads to lethality of the patient.

Keywords: Trigeminal neuralgia (TN or TGN), STEVENS-JOHNSON SYNDROME, Toxic epidermal Necrolysis, carbamazepine (Anticonvulsant), Baclofen (Muscle relaxant), Moderate (4b) type of reaction.