“PHARMACOLOGICAL & PHYTOCHEMICAL UPDATES ON CITRULLUS LANATA & CITRULLUS COLOCYNTHIS” - A REVIEW
Harinderjit Singh and Hayat M. Mukhtar*
ABSTRACT
Citrullus Species has been widely used in the preparations of folk medicine for centuries. Citrullus species has the traditional use in remedy for various diseases like cancer, endothelioma, leukemia, tumors of the liver, spleen etc. A decoction of the whole plant is made with juices used to help indurations of the liver. Roots may also be used as a purgative and for jaundice, urinary diseases, rheumatism and for snake poison. The leaves are diuretic and used in the treatment of jaundice and asthm. This plant is available in wild in the sandy lands of North West Punjab, Rajasthan, and southern coastal areas of India. Citrullus colocynthisis & Citrullus lanata commonly known as the colocynth, bitter apple, bitter cucumber and kaurtumba. It is a desert plant native to the Mediterranean basin and Asia. It resembles a common watermelon vine, bears, small, hard fruit with a bitter pulp. Lipoxygenase inhibitors may lead to the design of biologically and pharmacologically targeted inhibiting therapeutic strategies. Evaluation of Citrullus species extracts as a lipoxygenase inhibitor may be useful in cancer treatment. Evaluation of the fruit extract as a Inhibitor of hyaluronidase activity can be useful in the treatment of allergic reaction, snake bite poisoning, dengue and edema.
Keywords: Citrullus Species, folk medicine, lipoxygenase inhibitor, hyaluronidase Inhibitor, Xanthine Oxidase.
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