European Journal of Biomedical and Pharmaceutical Sciences

CONSEQUENCES OF BIOGENIC AMINES IN SETARIA DIGITATA ON CATTLE FILARIAL PARASITES

Manju D.* and Dr. K. Jeyakumar, Dr. S. Sujatha

ABSTRACT

The present study expressed the analysis of biogenic monoamines and their metabolites in Setaria digitata. It is almost dominantly present in the South East Asia and Western Pacific Regions. The present study was highlighted the lymphatic filarial worm of S. digitata in India. From the present study clearly revealed about the effect of diethyl carbamazine (DEC) on the levels of neurotransmitter amino acids and on the activities of related enzymes of S. digitata also accompanied with its efficiency on different parts of the body parts have been studied. Moreover, the present result clearly revealed about the four kinds of biogenic amines such as Serotonin, Histamine, Dopamine and Ephinephrinand. Based on the Diethyl Carbamazine level, whenever increased the concentration effect of Serotonin also been increased such as 38.7±3.1, 45.4±3.9, 51.4±3.7 range on 0.25, 0.5 and 0.7 Concentration of DEC (mM) respectively. Similarly the Dopamine, Histamine and Epinephrine or adrenaline also showed the when the concentration of DEC increased effect on the experimental sample possessed biogenic amines were increased. It was statistically significant result at the level of 0.01% of correlation co-efficient. Furthermore, the present work has been explained the activity of certain aminoacid metabolizing enzymes present in S. digitata. Apart from the result GOTb, GOTc, GDHa and GDHb maximum activity noticed on the whole worm, though the other two enzymes didn’t showed much more variations such as 0.046 ±0.013 and 0.145±0.01 of GOTb, GOTc respectively. Eventhough, amoung the four experimental parts reproductive tissue possessed GDHa maximum level 68.03±10.3 than remaining body parts also GOT b also manimum observed on fluid than the other three parts followed by GOTc maximum noted on muscle tissues.

Keywords: Effect of diethyl carbamazine (DEC), Serotonin, Histamine, Dopamine and Ephinephrin.