A FORMULATION & EVALUATION OF MUCOADHESIVE BENZOCAINE GEL
*Vasave Ranjit D., Valvi Dinesh R., Prof. Dusane Prachee K., Dr. Pawar Sunil P.
ABSTRACT
Gel dosage forms are successfully used as drug delivery systems considering their ability to control drug release and to protect medicaments from a hostile environment. The aim of this work was to investigate the properties of carbopol 934, HPMC K4M polymeric system in water-miscible co-solvents such as glycerin and alcohol. Benzocaine is a local anesthetic, treatment of mouth ulcer and mucosal pain relief. The mucosal gel formulation is applied in the treatment of dental pain Samples were prepared by simply dispersing different amounts of Carbopols (0.2-0.4%) into the alcoholic solution at the room temperature and were keep at 27,30 and 31°C. All these systems were then characterized for distribution, bio adhesiveness on the mucosa, physical stability and drug release. The Franz diffusion cell used to study in vitro drug release. The increase in carbopol concentration caused increased viscosity and bio adhesiveness. Neutralization of pH in various concentrations of carbopol gels showed resulted in increased viscosity. A relationship between the viscosity and bioadhesive strength was shown in the neutralized carbopol gels. On the other hand, the results indicated that increasing amount of carbopol 934,HPMC K4M and glycerine reduced drug release.
Keywords: Benzocaine, Carbopol934, HPMC K4M, Glycerin, Ethanol, Camphor.
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