PATTERN OF ADVERSE DRUG REACTIONS OF ANTIPARKINSONIAN DRUGS IN A TERTIARY CARE INSTITUTE
Dr. Ruchi Srivastava, Dr. Virendra Kushwaha*, Dr. Pooja Agrawal, Dr. Amit Kumar,
Dr. Himanshu Sharma and Dr. S. K. Barman
ABSTRACT
Aims: To assess the pattern of adverse drug reactions in patients receiving anti-parkinsonian drugs in tertiary care institute. Materials and Methods: A prospective, observational study was carried out from March 2018 to May 2019 at Department of Neuromedicine and Department of Pharmacology & Therapeutics, G.S.V.M. Medical College, after getting an approval from institutional ethical committee. Data was collected by analyzing OPD prescription slip, treatment charts and investigation reports. Adverse drug reaction reporting form provided by Indian Pharmacopeia Commission (IPC) was used for data collection. The ADRs were assessed for causality, severity and predictability. Total 45 patients were included in the study, out of which 31 patients came for follow-up. Result: During the study period, a total of 31 ADRs reported. Out of them 22(70.96%) were in males and 9(29.03%) were in females. Most of the ADRs were reported due to Levodopa+Carbidopa. Dizziness was most frequent ADR reported. Other ADRs observed were sedation, dry mouth, dyskinesia, drowsiness, blurred vision, discoloration of urine. Conclusion: Levodopa+Carbidopa is one of most widely used anti-parkinsonian drug and has a high potential to cause various effects in Parkinson’s disease patient. Most of the reactions were of mild severity and were predictable.
Keywords: Levodopa+ Carbidopa, Indian Pharmacopoeia Commission (IPC), Adverse drug reactions (ADRs).
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