EFFECT OF METFORMIN ON COMPLETE BLOOD COUNT, SERUM LEVEL OF B12, FOLIC ACID, AND CALCIUM IN PATIENTS WITH DIABETES TYPE 2
A. A. Saber*, W. A. Al-Dubai1, Z. H. Alh-Hammudi and Z. A. Atef
ABSTRACT
Aim of the study: This study determined the effect of metformin or sulfonylureas or both on CBC, B12, folic acid and calcium levels on type 2 diabetes patients. Method: This prospective cohort study was carried out in Diabetes Center of Al-Thawra Hospital in Sana'a City. Our study includes 96 newly diagnosed type 2 diabetes male patients receiving oral anti diabetic agents. They were divided into three groups: metformin, metformin combination therapy and sulfonylureas group. The patients were followed up during 3 months and the results before and after taking drugs were analyzed by SPSS statistical analysis. Results: Our result showed that, hemoglobin and hematocrit were significantly increased in all groups. The B12 level after treatment was significantly decreased in sulfonylureas group in comparing with metformin group by 32.39% (p value 0.02 4). The mean of eosinophil and calcium in metformin group were significantly increased (P =0.010, 4 x 10-4) respectively. Increase the calcium level in metformin group could explain the normal effect of B12 in this group. Conclusion: This study concluded the following: patients of type 2 diabetes treated with metformin will be exposed to increase hemoglobin, hematocrit, eosinophil and calcium levels. While patients treated with sulfonylureas will be exposed to increase in, hemoglobin, hematocrit levels and associated with decrease in B12 level.
Keywords: Metformin. Sulfonylureas, Diabetes type2, CBC, B12.
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