PROTECTIVE EFFECT OF CORIANDER (CORINDRUM SATIVUM) AGAINST LEAD TOXICITY IN RABBITS
Gehad Rashad Donia*
ABSTRACT
Bioactive compounds from natural sources can act as oxygen free radical scavengers or metal chelators, which enables them to be used as natural antagonists to heavy metals toxicity. So in this study aqueous and ethanolic extract of Coriandrum sativum seeds were evaluated for their potential hepato & renal protective and antioxidant effects in lead intoxicated rabbits. Oxidative stress was induced by a daily dose of lead acetate (40 mg/kg body weight by oral gavage) for seven days. After that animals received an oral dose of coriander extracts (aqueous and ethanolic) daily to the end of the experiment. The effect of these treatments in influencing the lead induced changes on liver and kidney functions, oxidative stress, and histopathological alterations in liver and kidney were studied. The data showed elevation of ALT, AST, ALP, urea and creatinine in serum, increase in oxidative stress markers MDA levels in animals treated with lead acetate while the effect was attenuated by coriander seed extracts. Lead decreased the antioxidant enzymes activities and this effect was reversed in groups treated with coriander extracts. Also, extracts exhibited some improvement in the histological architecture of liver and kidney. From the findings of this study, the coriander is identified to possess antioxidant potential and hence it is worth to be considered as a natural chelating agent for lead intoxication.
Keywords: Coriandrum sativum, Lead, Oxidative stress, hepatotoxicity, nephrotoxicity, Rabbits.
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