Abstract
SALT AND NON-SALT FORMING EXCIPIENTS TO IMPROVE THE DISSOLUTION OF DEXIBUPROFEN; FORMULATION OF CHEWABLE TABLETS

Dalia Naeem*, Mohamed Osman, Gamal El Maghraby, Ebtessam Essa

ABSTRACT

Dexibuprofen is a stronger non-steroidal anti-inflammatory drug than ibuprofen but with less gastric damage. However, it suffers poor aqueous solubility. This work improved Dexibuprofen dissolution via co-processing with inert excipients with the aim of formulating chewable tablets. Wet co-grinding of Dexibuprofen with increasing proportions of mannitol or meglumine was performed after liberation from their ethanolic solutions. The prepared mixtures were investigated using differential scanning calorimetry, Fourier Transform Infrared spectroscopy, powder X-ray diffraction and dissolution behavior. Optimum co-processed mixtures were prepared into chewable tablets after addition of suitable additives. Wet co-grinding improved drug dissolution parameters compared to unprocessed one, with meglumine being superior to mannitol. Solid state characterizations reflected possible salt formation between the drug and meglumine. For mannitol mixtures, dissolution enhancement was attributed to partial amorphousization of Dexibuprofen along with particle size reduction. The selected co-processed mixtures were successively formulated into chewable tablets. In vitro dissolution studies were performed using crushed as well as intact tablets. Mannitol based tablets showed prompt drug release in both cases. However, meglumine based tablets required crushing for fast drug release indicating the need for chewing. The study introduced simple co-processing as a tool to enhance dissolution rate of Dexibuprofen with subsequent formulation of chewable tablets.

Keywords: Dexibuprofen, mannitol, meglumine, salt form, co-grinding.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW APRIL ISSUE PUBLISHED

    APRIL 2020 Issue has been successfully launched on 1 April 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT