European Journal of Biomedical and Pharmaceutical Sciences

EARLY SERUM LIPID PROFILE IN PRETERM INFANTS AND ITS RELATION TO RESPIRATORY DISTRESS SYNDROME IN SHENDI LOCALITY, NORTH SUDAN

Umniah M. A. Busharh*, Mamoun Mekki Elmanna, Haghamad Allzain and Khaled H. Bakheit

ABSTRACT

Essential lipids malnutrition can affect maternal health and lead in preterm birth to higher incidence of neonatal respiratory distress syndrome. The objective of this study was to investigate early serum lipid profiles in preterm infants and their relationship with development of neonatal respiratory distress syndrome (RDS). This study was cross sectional, hospital based prospective case control study, conducted at the obstetrics and gynecology department in Elmak Nimer university hospital in Shendi town, River Nile state, north Sudan from October 2017 to April 2019. The study included 160 appropriate-for-gestational-age (AGA) preterm infants, subdivided into three group according to their gestational age and the presence or absence of RDS. Another 50 AGA healthy full term newborns were randomly selected as control group. Umbilical cord venous blood was collected from all of them. Lipid profile (Total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride (TG) were measured. Ninety-three infants developed Respiratory Distress Syndrome. RDS cases significantly increased P. value of (0.000). There was significant higher serum concentration level of TC and LDL with P. value of (0.000) and non-significant high HDL with lower birth weight. There was also significant increase of TG with higher birth weight. There was a significant decrease of TC and LDL in RDS, with P. value of (0.000) and non-significant of lipoprotein HDL and TG in RDS.

Keywords: Neonates, Preterm, Respiratory Distress Syndrome (RDS), Gestational age (GA) Lipids profile, TC, LDL, TG, HDL.