EVALUATION OF CARDIOMETABOLIC RISK FACTORS IN CHRONIC KIDNEY DISEASE
Dr. Kulkarni Sweta*, Dr. R. Reeta, Dr. R. Ramesh, Mr. Kulzhandai Velu, Dr. Hemachandar.R, Mr.Saravana
ABSTRACT
Introduction: Chronic kidney disease (CKD) is defined as the persistent kidney damage confirmed by renal biopsy or markers of kidney damage and/or glomerular filtration rate (GFR) < 60ml/min/1.73m2 for greater than 3 months. Cardiovascular disease is the leading cause of death in patients with CKD rather than ESRD. Metabolic and cardiovascular complications of renal disease may be consequence of abnormal insulin action and obesity. Hence in the present study waist to height ratio, insulin resistance, TAG: HDL ratio and proteinuria were studied as cardiometabolic risk factors in CKD. Materials and Methods: 60 patients newly diagnosed as CKD in the age group between 20-60 years were selected for the study. Patients taking ACE inhibitors, lipid lowering drugs, antioxidants, hormonal therapy and in End stage renal disease were excluded from the study. Statistics: One sample `t` test was done to know the significance of all parameters in CKD. PEARSON`S correlation was done to know association between study parameters with creatinine and P<0.05 was taken as statistically significant. Result: Statistically significant increase in waist to height ratio, TAG: HDL ratio, HOMA-IR and urine albumin was found in CKD patients after doing one sample t test. Statistically significant correlation was not found between serum creatinine, insulin resistance, TAG: HDL ratio and urine albumin. Conclusion: Cardiometabolic risk factors waist to height ratio, TAG: HDL ratio, HOMA-IR and urine albumin were significantly elevated in CKD patients but longitudinal studies have to be undertaken to establish the significant correlation between study parameters. The present study enlightens the significance of anthropometric and biochemical markers as cardiovascular risk factors in CKD.
Keywords: Chronic kidney disease, cardiometabolic risk factors, TAG: HDL, HOMA-IR, waist to height ratio, creatinine.
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