Abstract
PREFORMULATION STUDIES OF TRAMADOL HCL: VITAL PART OF FORMULATION DESIGN

Surendra Pratap Singh Parihar* and Himesh Soni

ABSTRACT

Preformulation study is a fraction which is initiated once the new molecule is seeded. In a broader way, it deals with studies of physical, chemical, analytical, and pharmaceutical properties related to molecule and provides idea about suitable modification in molecule to show a better performance. Preformulation parameters study can be linked to generation of effective, safer, stable, and reliable pharmaceutical formulation. Tramadol Hydrochloride is a centrally acting synthetic opioid analgesic. The mode of action is not clear, even though the parent and metabolite of Tramadol binds to μ-opioid receptors and results in weak inhibition and reuptake of nor-epinephrine and serotonin. In the present works overall objective of preformulation studies of Tramadol HCl is to generate information useful in developing stable and Bioavailable dosage forms.

Keywords: Preformulation study, Tramadol HCl, Solubility & Analytical methods.


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