European Journal of Biomedical and Pharmaceutical Sciences

DE-ESCALATION OF ANTIBIOTICS-AN EFFECTIVE TOOL AMONG PATIENTS AT ADESH HOSPITAL, BATHINDA, Pb.

*Singh Harinderjit, Patil H. C. and Patil R. K.

ABSTRACT

Patients admitted to Intensive therapy units (ITU) are critically ill patients and most often associated with infection or gets associated with infection due to their prolonged stay in hospital and due to the various invasive treatment options like catheter, tracheotomy tube, ventilation etc that they are treated with and due to the prevailing hospital flora. Strategy of de-escalation practice can be an optimal approach in preventing spread of antibiotic resistance by optimizing the usage of antibiotic thereby reducing pressure on bacterial ecology; as each antibiotic used, appropriate or inappropriate affects bacterial ecology by exerting selective pressure and thus driving resistance and thereby causing potential public health consequences. The antibiotics must be used in a manner that will ensure not only minimum subsequent antimicrobial resistance but also ensure maximum favorable outcome for the individual patient. this strategy of de-escalation practice can be an optimal approach in preventing spread of antibiotic resistance by optimizing the usage of antibiotic thereby reducing pressure on bacterial ecology; as each antibiotic used, appropriate or inappropriate affects bacterial ecology by exerting selective pressure and thus driving resistance and thereby causing potential public health consequences (Deresinski, 2007). Though a number of factors are at root cause of the problem the core factor is surely correlated with the extensive and extensively inappropriate use of antibiotics in hospitals especially in the Critical Care Units, where infections are common day-to-day problem.

Keywords: De-escalation, Antibiotics, Antimicrobial etc.