European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLET OF CHLOROPHENIRAMINE MALEATE

*Kanna Reshma, Manda Nagamani, Ragini Karra, Pulicheri Mounika

ABSTRACT

To develop Oro dispersible tablets of Chlorphenaramine Maleate to achieve rapid disintegration, dissolution to resolve the swallowing problems in Paediatric, Geriatric patients by rapid disintegration in saliva and improve the patient compliance. Oral route is the widely used route for the administration of any type of dosage form and can be made a best route by overcoming its drawbacks. Immediate release tablets by using a super disintegrant solved the problems encountered during the medication through oral route. In the present work, an attempt has been made to develop fast disintegrating tablets of Chlorphenaramine Maleate. New generation super disintegrates Polyplasdone XL, Vivasole and Explotab was selected as super disintegrates. All the formulations were prepared by Direct Compression method using 6mm punch on 10 station lab press tablet Compression Machine. The blend of all the formulations showed good flow properties such as Angle of repose, Bulk density, Tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F6 formulation showed maximum % drug release i.e., 99.89% in 18±0.01 sec hence it is considered as optimized formulation.

Keywords: Oro Dispersible tablets of Chlorphenaramine Maleat, Dissolution, Formulation and evaluation.