European Journal of Biomedical and Pharmaceutical Sciences

COMPARISON OF MESOPOROUS SILICA XEROGEL, AMINO-FUNCTIONALIZED MESOPOROUS SILICA XEROGEL AND PARTECK SLC FOR LOADING AND RELEASE RATE OF NICARDIPINE HYDROCHLORIDE

Potdar Dipali*, Dr. Bele Mrudula, Nemane Dipak, Nikam Vishal and Lahane Ajay

ABSTRACT

Purpose: Nicardipine hydrochloride is an antihypertensive drug which blocks the calcium channel. It belongs to the BCS class II having high lipophilicity, poor water solubility and hence low bioavailability. The main aim of this study is to synthesized MSX, AMSX by using biomimetic method and also marketed parteck SLC carrier is used to check its ability to be a good drug carrier for loading and release rate of poorly water soluble drug NH. This drug loaded xerogel is compared with drug loaded parteck SLC. The dissolution media was developed for performing the in vitro dissolution of nicardipine hydrochloride. The porous silica were synthesized by using sol-gel method. These silica carriers then loaded with drug by using in-situ inclusion method and evaluated by performing in vitro dissolution study in developed dissolution media. Also the drug is loaded in marketed parteck SLC by using solvent evaporation method (1:1,1:2,1:3) and evaluated by performing in vitro dissolution study. Methods: The synthesized MSX,AMSX,NH-MSX,NH-AMSX was studied by using SEM. Then MSX, AMSX, NH-MSX, NH-AMSX and NH-PS (1:1,1:2,1:3) characterized by XRD, DSC, and ATR. Results: The in vitro drug release study revealed that the amino functionalized mesoporous silica xerogel show highest drug release (97.08%) followed by mesoporous silica xerogel (79.95%) and Parteck SLC(1:2)(68.33%). From XRD study, it can be seen that the mesoporous silica and drug loaded formulation showed no typical crystal peak, which suggest that the drug is converted into amorphous form after it is being loaded in MSX, AMSX and Parteck silica SLC. DSC study showed that nicardipine hydrochloride loaded mesoporous carriers [NH-PS (1:1,1:2,1:3)] endothermic peak due to the melting of nicardipine hydrochloride was not observed which denoted the amorphous nature of nicardipine hydrochloride in the mesoporous carriers. In case of drug loaded mesoporous silica xerogel (NH-MSX,NH-AMSX) a broad endothermic peak was observed near 259.30C and 258.60C which represents the presence of amorphous form of nicardipine hydrochloride in NH-MSX,NH-AMSX. Conclusion: From the results AMSX showed the higher loading capacity and enhanced dissolution release can be considered to be a good candidate as drug carrier for NH.

Keywords: Mesoporous silica xerogel, Parteck SLC, NH-MSX, NH-AMSX.