European Journal of Biomedical and Pharmaceutical Sciences

ASSESSMENT OF APHRODISIAC EFFECTS IN MALE AND FEMALE ANIMALS, ACUTE AND SUBACUTE TOXICITY OF DIAZOSTIMUL

Ntondele L. M., Nsompi M. P. and Cimanga K. R.

ABSTRACT

Heinsia crinita (Afzel) Taylor is a medicinal plant currently used in traditional medicine in many African countries to treat various diseases including erectile dysfunction because of its aphrodisiac property empirically known by many people who use an aqueous macerate or decoction for this medical purpose. Nowadays, this aqueous extract is put in an ameliorated galenic form as tablets and called Diazostimul as a natural aphrodisiac product. In the present study, Diazostimul aqueous extract was evaluated in animal model for its aphrodisiac property. Results revealed that the oral administration of this extract in treated male Wistar rats leaded to significant increase of some sexual parameter behaviors such as mount intromission or mount frequency, intromission frequency, penile erection, penile trusting, ejaculation frequency, copulatory efficiency, number of sperm and penile ejaculation interval. On the other hand, other sexual parameters like mount frequency, intromission latency, ejaculation latency known significant decrease. It also showed good potency, ability, motivation, arousability, performance and vigor in treated male animals. All these effects clearly demonstrated that Diazostimul aqueous extract possessed aphrodisiac property. The administration of the extract also significantly increase the level of sexual orientation, oeastradiol, testosterone, production of sperm, motility and fertility in male animals,. In addition, it did not significantly affect the haematological and biochemical parameter concentrations and weight of vital organs of treated animals. It in contrary, it influenced the concentration of some electrolytes. In acute and subacute toxicity testing, results showed that Diazostimul is a safe drug without any toxic effect. They support and justify the current use of this natural medicine by many people in their daily sexual relation where there find great satisfaction.

Keywords: Heinsia crinita, Rubiaceae, root bark, Diazostimul, aqueous extract, aphrodisiac, acute and subacute toxicity.