European Journal of Biomedical and Pharmaceutical Sciences

SYSTEMIC IMMUNE-INFLAMMATION INDEX AS A MARKER OF SUBCLINICAL INFLAMMATION IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER

*Sena Ulu, Sinan Kazan, Elif Dizen Kazan and Onur Tunca

ABSTRACT

Background: Although FMF is a disease with episodes, subclinical inflammation may be present in the intermittent period. Systemic immune-inflammation index is a new, cheap and easily accessible inflammatory marker. Objective: In this study, we aimed to compare SII index in FMF patients in terms of subclinical inflammation , when they were attack-free and healthy controls. Besides, we aimed to investigate the relationship between the frequency of FMF attacks and SII index measured in the period without FMF attack. Methods: The analysis was performed with 173 FMF patients and 20 healthy subjects. All patients who met the diagnostic criteria of Tel-Hashomer followed by nephrology outpatient clinic were involved in this retrospective study. As the control group, all health workers who work in our hospital in internal medicine department were examined. Systemic immune-inflammation index was calculated as (absolute neutrophil count x platelet count)/absolute lymphocyte count. All patients were required to be at least 2 months of attack-free period and control group was also required to have no signs of active infection at the time of calculating the SII index. Results: Systemic immune-inflammation index was significantly higher in FMF patients than controls (583,08±362,1 and 381,38±123,9 respectively, p=0,016). Systemic immune inflammation index was also correlated with the frequency of annual attacks (p<0,001 and r=0,458). Conclusion: This the first study investigating the SII index in FMF patients. The SII index may be considered as a new, easily accessible and inexpensive indicator of inflammation in FMF patients.

Keywords: Systemic immune-inflammation index , Amyloidosis, C-Reactive Protein, Familial Mediterranean Fever, Inflammation, Serum Amyloid A.