CHALCONES AND HETEROCYCLIC COMPOUNDS: A REVIEW ON SYNTHESIS AND EVALUATION OF THEIR ANTIBACTERIAL, ANTIMICROBIAL, ANTI-INFLAMMATORY AND ANTILESHMANIAL ACTIVITY
G. N. Lodhi*, S. S. Trivedi and C. A. Doifode
ABSTRACT
Chalcones are an important class of natural products and are considered as the precursors of flavonoids and isoflavonoids. Chemically, chalcones are 1,3-diaryl-2-propen-1-ones in which two aromatic rings are joined by a three carbon bridge having a carbonyl moiety and α, β unsaturation. The compounds with the backbone of chalcones have been reported to possess various biological activities such as antimicrobial, anti-inflammatory, analgesic, anti platelet, anti ulcerative, anti 0malarial, anticancer, antiviral, anti leishmanial, antioxidant, anti-tubercular, anti-hyperglycemic, immunomodulatory, inhibition of chemical mediators release, inhibition of leukotriene B4, inhibition of tyrosinase and inhibition of aldose reductase activities. This paper mainly focuses on chalcones synthesized by Claisen Schmidt condensation which involves the condensation between an aromatic aldehyde or ketone with an aliphatic ketone or aldehyde catalysed by the presence of dilute alkali or acid to form alpha beta unsaturated compound. through reviewing different biological significance of chalcones and their derivatives have been reported along with their chemistry and of synthesis.
Keywords: Chalcone, Aldol condensation, Claisen Schmidt condensation, Pharmacological / Biological activity.
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