STUDY OF MUCOADHESIVE EFFECT OF MORINGA OLIFERA GUM ON GASTRORETENTIVE TABLET OF BACLOFEN
Sujatha P. Muchalambe*, Sunil Kumar V., Suma U. S. and Mamatha M. K.
ABSTRACT
The objective of the study is to study the mucoadhesive effect of natural gum obtained from Moringa oleifera as tablet mucoadhesive polymer. This property of the gum was evaluated and compared with standard syntactic polymers like PVP K30, HPMCH4M for mucoadhesion. In this current study Baclofen is used as a model drug, where Baclofen has the absorption window in upper GI track and due to this often display low bio-availability, the half-life of the drug is 2.5-4hrs. The comparability of polymer and drug are carried by FTIR. The mucoadhesive tablet of different ratio of Moringa, HPMCK4M and PVPK30 tablet are formulated and evaluated for mucoadhesive time, mucoadhesive strength, swelling index. Dissolution study was conducted to characterize release mechanism of the formulation and data are fitted to various kinetic models. Stability study for optimized formulation B at 400 ±20C/75±5%RH for 90 days. It could be concluded that the gum Moringa oleifera can be used as a pharmaceutical Excepients in oral mucoadhesive drug delivery system.
Keywords: Moringa oleifera, Gum, Mucoadhesion, HPMCK4M, PVP30K.
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